Monogenic diabetes: recent updates on diagnosis and precision treatment: A narrative review

Monogenic diabetes is commonly caused by single-gene mutations. This disease ranges from 1% to 5% in all cases of and less affected behavior environment. Neonatal mellitus (NDM) maturity-onset the young (MODY) account for a major proportion monogenic diabetes, while syndromic constitutes smaller proportion. Diagnosis has improved being based on clinical phenotypes molecular genetics, with significant advancement genome sequencing skills. Precise medication genetic testing; therefore, an accurate diagnosis essential. Due basic criteria (diagnosed < 6 months age), testing precision treatment NDM are fast uncomplicated. The MODY probability calculator was developed; however, it remains challenging distinguish type 1 2 due lack single diagnostic testing. Additionally, high cost complicated interpretation these test results add challenges. review will discuss distinct etiology subgroups that contribute predicting treating associated diabetes. Furthermore, we recent Korean studies suggest methods prioritizing patient screening